Dr. Puya Yazdi is a physician-scientist with 14+ years of experience in clinical medicine, life sciences, biotechnology, and nutraceuticals. The Coronavirus pandemic is causing a lot of extra stress and anxiety, which can actually weaken your immune system and put you more at risk. 8, 9 Baicalin has multiple biologic effects, including anti-inflammatory, 10, 11 anti-tumor, 12 anti-bacterial, 13 anti-viral, 14 and antioxidant functions. Baicalin (14) and its aglycone baicalein (15) are flavones that exhibit a variety of biological effects, including anti-inflammatory and anticancer properties. Learn how your comment data is processed. Synergistic effects of baicalin with levofloxacin on 3- (A-F) and 7-day (G-L)-old biofilms, as determined by SEM (8000 ×). Wei Zhang, ... Yi-Jing He, in Handbook of Pharmacogenomics and Stratified Medicine, 2014. Pure baicalin improved lung function in rats suffering from allergic diseases [10]. Rats with alcohol-induced liver damage treated with this flavonoid before consuming alcohol had protective effects on the liver. I have a lot of experience with chamomile tea, and 500mg of baicalin does more for me than maybe two bags of chamomile … MPTP-lesioned mice treated with baicalein (11) or its aglycone baicalin (12) improved motor dysfunctions and prevented dopaminergic neuronal loss (Gao et al., 2015, p. 155; Xue et al., 2014, p. 54). Several studies documented the anti-inflammatory properties of baicalin (Lee et al., 2015; Li et al., 2000; Lin and Shieh, 1996). Baicalin (7-glucuronic acid, 5, 6-dihydroxyflavone) is the major flavonoid isolated from dry roots of Scutellaria baicalensis Georgi. It is widely distributed in the plants of the genus Scutellaria (Lamiaceae) as a major constituent of fruit, root bark, and leaves while baicalin is found in abundant quantities in leaves and stem bark. In mice, baicalin produced anxiety-lowering effects without causing drowsiness or muscle relaxation [3]. In mouse embryos, it increased the development and quality of blastocysts [16]. Figure 44.9. We do not aim to diagnose, treat, cure or prevent any illness or disease. This compound exhibited many different pharmacological activities, including antiviral activity and photoprotective effects against acute and multiple UVB-induced photodamage associated with reduction of oxidative stress (Nayak et al., 2014; Wang et al., 2013a,b; Zheng et al., 2014). Flavonoids usually have poor bioavailability, and baicalin is no exception [. Baicalin is found in traditional Japanese herbal medicines for eye health [14]. In another study, baicalein significantly attenuated renal fibrosis by reducing the accumulation of fibronectin and collagen through downregulation of the epithelial-mesenchymal transition (EMT) process and fibrogenic cytokines such as TNF-α, IL-1β, and MCP-1 expressions via inactivation of the NF-κB and MAPK signaling pathways.77, Ravirajsinh N. Jadeja, Ranjitsinh V. Devkar, in Polyphenols in Human Health and Disease, 2014, Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc.36 Based on previous reports on pharmacological modulation of diabetes, hyperlipidemia and atherosclerosis by Scutellaria baicalensis extract,37–39 Guo and colleagues40 were tempted to evaluate the protective effects of baicalin (1) in modulating experimentally induced NASH. Other flavones, such as baicalin, wogonin and apigenin, are also often distilled from these plants. In addition, baicalin reversed the hypoxia-induced reduction of p27 and increased AKT/protein kinase B phosphorylation both in vivo and in vitro (Zhang et al., 2014). Baicalin is a flavone glycoside, the glucuronide of baicalein, which is obtained through the binding of glucuronic acid to baicalein. Baicalein, aka 3,4,5-trihydroxyflavone, is a naturally-occurring phenolic flavone isolated from the plant Scutellaria baicalensis. Thus, baicalin reduces plasma concentrations of rosuvastatin in an OATP1B1 haplotype-dependent manner. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. One study found that an 800 milligram (mg) dose of baicalein gave rise to plasma concentrations of 0.029 ug/mL baicalein within 4 hours, while it gave rise to a much higher plasma concentration of 0.396 ug/mL baicalin by 3.5 hours. He was also a Medical Director for Cyvex Nutrition before serving as president of Systomic Health, a biotechnology consulting agency, where he served as an expert on genomics and other high-throughput technologies. Yangchun Xie, ... Daolin Tang, in Dietary Interventions in Liver Disease, 2019, The pharmacological effects of S. baicalensis may depend on the digestive system and intestinal bacteria metabolism.13–16 Four main types of flavonoids, including baicalin, baicalein, wogonoside, and wogonin, have been identified from S. baicalensis. This herb has been part of traditional Chinese materia medica for millennia and is used to treat pain and inflammatory conditions. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Baicalein is one of the active ingredients of Sho-Saiko-To, a Chinese herbal supplement believed to enhance liver health. Your email address will not be published. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. It was shown that baicalin (80 mg/kg), administration to high-fat diet (HFD)-fed rats for 16 weeks was able to reduce body weight gain and visceral fat mass. It is widely distributed in the plants of the genus Scutellaria (Lamiaceae) as a major constituent of fruit, root bark, and leaves while baicalin is found in abundant quantities in leaves and stem bark.70 The antiinflammatory potential of baicalin and baicalein has been confirmed in that both molecules can be potent agents for the treatment of rheumatoid arthritis, respiratory diseases, inflammatory bowel diseases, cardiovascular diseases, hepatitis, kidney diseases, and neurodegenerative diseases. Baicalin is a flavone glucuronide purified from the medicinal plant Radix scutellariae through uridine diphosphate glucuronidation. Rosuvastatin (20 mg orally) pharmacokinetics after coadministration of placebo and 50-mg baicalin tablets (three times/day orally for 14 days) were measured for up to 72 h in a two-phase randomized crossover study. administration of baicalein vs. that in control situation. Figure 23.4. PAH is a cardiovascular disease characterized by enhanced pulmonary artery smooth muscle cell (SMC) proliferation and suppressed apoptosis (Zhang et al., 2014). Baicalein is a trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. Join SelfHacked today and start the journey of improving your life, 2020 Causing Extra Stress? It is primarily used in Asian countries as an herbal supplement. Further, baicalin-treated rats showed improved levels of serum cholesterol, free fatty acid, insulin and TNF-α compared to HFD rats. It is similar in pharmacophore to other flavones such as apigenin, K36, and baicalin (the latter of which is a less bioavailable prodrug for baicalein). However, the studies listed below should not be interpreted as supportive of any health benefit. His previous clients include Allergan, Caladrius Biosciences, and Omega Protein. Learn more here. When taken orally in rats for 7 days it increases the activity of T helper cells and T regulatory cells to fight chemically-induced colon cancer [22]. Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflorathat have a wide variety of health benefits. He has a history of peer-reviewed publications, intellectual property discoveries (patents, etc. Align your health hacks with your genes for optimal health & cognitive function. Baicalein is a flavonoid originally isolated from the traditional medicinal herb Scutellaria baicalensis Georgi with known neuroprotective and anti-inflammatory effects in models of neurodegenerative disorders, including PD models. . December 1, 2018 ~ Simon ~ 14 Comments . Effect of baicalin and baicalein on viability of OVCAR-3, CP70 and IOSE-364. However, CsA has a narrow therapeutic range and large interindividual pharmacokinetic variability. Hsc70 serves as a loading control. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Baicalein is well absorbed by passive diffusion (40% absolute absorption) and extensively glucuronidated to baicalin and baicalein 6-O-glucuronide by UGT in either the small intestine or the liver in vivo (Lai et al., 2003). Therefore, drugs able to block the pathological changes of keratinocytes will be useful for the treatment of patients affected by psoriasis. ), clinical trial design, and a thorough knowledge of the regulatory landscape in biotechnology.He is leading our entire scientific and medical team in order to ensure accuracy and scientific validity of our content and products. Recently I wrote a post about research investigating an interesting compound called Epigallocatechin gallate (or EGCG – click here for that post). Baicalein reduced lung inflammation by inhibiting Th17 cells in the lungs [12]. Rajesh Shukla, ... Santram Lodhi, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second Edition), 2019, Baicalin is a flavone glycoside and after its hydrolysis it converts into aglycone (baicalein). It is primarily used in Asian countries as an herbal supplement. Save my name, email, and website in this browser for the next time I comment. It's supposedly a "mild anxiolytic" but I say that it is more than mild. 23.4) is one of the main constituents responsible for the pharmacologic actions of Scutellaria baicalensis, a Chinese herbal medicine used for centuries to treat psoriasis. Baicalein 6-O-β-D-glucopyranuronoside has been, however, reported to be the main metabolite in the plasma after oral administration of baicalin (Akao et al., 2013). Zhai W, Eynott PR, Oltmanns U, Leung SY, Chung KF. Required fields are marked *. Eighteen unrelated healthy volunteers who were CYP2C9*1/*1 with different OATP1B1 haplotypes (six OATP1B1*1b/*1b, six OATP1B1*1b/*15, and six OATP1B1*15/*15) were selected to participate in this study. a 6133 MPL/W515L cells were treated with or without baicalein (0, 10, and 20 µM) for 12 h and subjected for Annexin V staining (PE-conjugated antibody) to measure apoptosis.b The treated cells were collected for western blot to detect cleaved caspase 3 as an apoptotic marker. The UPS is the principal mechanism for damage protein degradation, and its activity was shown to be reduced in PD (Kaushik and Cuervo, 2015, p. 1406; Vilchez et al., 2014, p. 5659). Sometimes, Scutellaria lateriflora (North American skullcap) is mistaken for S. baicalensis Ovarian cancer is one of the primary causes of death for women all through the Western world. Our goal is to not have a single piece of inaccurate information on this website. Baicalein induced apoptosis in 6133 MPL/W515Lcells. The C max of baicalin (a major baicalein conjugate) (5.0 ± 0.7 nmol/mL) was reached at 0.5 h with a long elimination half-life (t 1/2) of 11.8 h . A relatively small number of other flavonoids are produced from S. baicalensis Georgi, including viscidulin III-2-O-b-D-glucoside, 5,7,2′,5′-tetrahydroxyflavone, (-)-eriodictyol and rivularin, chrysin 8-C-b-D-glucopyranoside, 5,2′-dihydroxy-6,7,8,3′-tetramethoxyflavone, and skullcapflavone I.3, After taken orally, the two glycosides (baicalin and wogonoside), which cannot be absorbed directly though the intestine, are hydrolyzed in the digestive tract and can be taken up and absorbed in their aglycon forms, namely baicalein and wogonin, respectively.14,15 It is worth mentioning that the gut microbiota play a critical role in the orally taken pharmacokinetics of the glycosides; studies on incubation with digestive juice in vitro and pretreatment of antibiotics in vivo demonstrate that this metabolism into aglycons is compromised.13,16, Once passing though the intestinal wall, aglycons are glucuronidated into glycosides in a ratio of approximately 20:1 to enter the systemic circulation. Its active constituents include baicalin, a flavonoid, the herb’s most studied component. Joe Cohen won the genetic lottery of bad genes. Vibhavari Sail, M. Kyle Hadden, in Annual Reports in Medicinal Chemistry, 2012. In vitro experiments had also shown that dosing of baicalin (5 and 10 μmol/L) to high glucose-exposed HepG2 cells resulted in increased AMP-activated protein kinase (AMPK) phosphorylation and decreased hepatocyte lipid accumulation.40, Marc Morissette, ... Thérèse Di Paolo, in Discovery and Development of Neuroprotective Agents from Natural Products, 2018. It is important to use the Latin name, as the term 'skullcap' is used for over 200 varieties. In 6-OHDA-lesioned rats, baicalein (11) attenuated muscle tremor and restored metabolic balance between glutamate and γ-aminobutyric acid (GABA) in the basal ganglia and inhibition of cytochrome oxidase I in the subthalamic nucleus (Yu et al., 2012, p. 5). Tag: baicalin Thyme to look east: Baicalein. Baicalin and baicalein are naturally occurring flavonoids that are found in the roots and leaves of some Chinese medicinal plants and are thought to have antioxidant activity and possible anti-angiogenic, anti-cancer, anxiolytic, anti-inflammatory and neuroprotective activities. Copyright © 2020 Elsevier B.V. or its licensors or contributors. In psoriatic patients, under the influence of proinflammatory cytokines, keratinocytes express several growth factors and cytokines involved in the immune responses that in turn drive angiogenesis. Solomon Habtemariam, in Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases, 2019. In this study, the maximum plasma concentration (C max) of baicalein was used. Herb–drug interaction between rosuvastatin and baicalin is OATP1B1 genotype-related. Generally, results obtained in this study suggested that 5% baicalin cream was a promising agent for psoriasis treatment. 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